T
Как ДНК-тест поможет похудеть, выглядеть моложе и эффективнее заниматься спортом?
Во всем мире набирает обороты ДНК-туризм: люди, сдав ДНК-тест на генеалогию, едут путешествовать по местам своих предков. Увлекательно, согласна. Но если подходить к теме генетики с точки зрения здоровья и красоты, то гораздо полезнее ДНК-тесты, которые фактически предоставляют инструкцию по максимально эффективному управлению организмом. О том, как использовать эти данные, я поговорила с генеральным директором Genotek Валерием Ильинским.
Как ДНК-тест может помочь в подборе правильного питания?
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«Существует отдельная наука — нутригенетика, которая изучает взаимосвязь наших генов с особенностями питания. Каждое питательное вещество (жиры, углеводы, витамины и т. д.) усваивается организмом по определенной цепочке, которая состоит из белков. Они могут быть более активными или менее. Таких цепочек очень много, поэтому каждый из нас по-разному усваивает разные продукты. Кто-то хорошо переносит лактозу, а кто-то нет, кто-то переносит глютен, а кто-то нет. То же самое с витаминами — разный уровень усвояемости у каждого человека. Чей-то организм быстро усваивает витамин из пищи, а потом его быстро выводит. В результате у человека нехватка определенного витамина. Организм другого человека тоже хорошо усваивает тот же витамин из пищи, но медленно выводит. И у этого человека достаточное количество или избыток этого витамина».
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Это все можно увидеть в результатах ДНК-теста?
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«ДНК-тест не покажет нынешнее состояние человека. Но с помощью теста мы можем сказать, как работает его организм. Если человек одновременно сдает ДНК-тест и вместе с этим анализ на текущее состояние витаминов, крови, волос, ногтей, то можно, сопоставив эту информацию, сказать, как стоит скорректировать диету для того, чтобы уровень витаминов был такой, какой рекомендован. Например, у человека нехватка витамина С в данный момент. Мы знаем, что с усвоением витамина С все в порядке, просто он не получает его с пищей. Это компенсируется подбором витаминов либо продуктами с содержанием витамина С. И наоборот, может быть ситуация, когда у человека нехватка витамина С, и мы видим, что причина в генетике самого человека (тот случай, когда витамин быстро выводится из организма). Тогда надо рекомендовать ему потреблять гораздо больше витамина С, чем положено по норме. Поэтому, имея данные ДНК-теста и анализов на витамины и микроэлементы, диетолог может скорректировать ваше питание и сказать, что нужно делать, чтобы уровень каждого элемента был в норме».
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А популярная когда-то диета по группе крови близка к нутригенетике?
«Диета по группе крови изначально была профанацией. Группа крови никак не связана с обменом веществ. Про эту диету мне рассказывали, что у ее изобретателей была идея придумать нечто персонализированное, предложить каждому человеку что-то специально разработанное для него. И тест по группе крови — очевидный способ разделить людей на группы. Затем было разработано несколько диет, которые одинаково эффективны. Что нужно, чтобы похудеть? Тратить калории. На этом построили четыре диеты и приписали их разным группам крови».
Как ДНК-тест может помочь в занятиях спортом?
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«Определенные варианты генов по-разному участвуют в откладывании подкожного жира. Например, есть такие люди, у которых в результате силовых упражнений толщина подкожно-жировой клетчатки увеличивается, то есть жир не сжигается, а накапливается. Таких людей немного, всего несколько процентов, но они есть. Если они хотят сжечь жир, то силовые упражнения не приведут их к тому результату, который они хотят получить. Организм каждого человека в целом по-разному реагирует на физические упражнения. Кто-то очень быстро сжигает жир, как только начинает тренироваться. Кто-то, наоборот, это делает очень медленно. Это определяется генетикой, насколько быстро организм умеет задействовать жировые запасы, превращая их в энергию, которая тратится в ходе упражнений».
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А кроме взаимосвязи тренировок и сжигания жира что я могу узнать?
А кроме взаимосвязи тренировок и сжигания жира что я могу узнать?
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«Информацию, связанную с риском травм. У кого-то постоянные вывихи, кто-то мучается с последствиями сотрясения мозга. Это тоже связано с генетикой. Наши связки состоят из разных белков — они могут быть более или менее прочными. Если менее — человек легко получает вывих. Конечно, плотность тканей зависит в том числе от питания и образа жизни, но существует генетическая предрасположенность. Также существуют определенные маркеры, которые повышают или снижают риск переломов, сотрясения головного мозга. При сотрясении головного мозга образуется токсичный выброс, который направляется в головной мозг. Если организм умеет быстро выводить эти токсины, то даже при возникновении травмы никакого риска для головного мозга нет. Но если организм не умеет их выводить, то происходит отравление головного мозга. Эти знания помогут выбрать вид спорта с учетом возможных травм».
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Как ДНК-тест может помочь выглядеть моложе?
«За процесс старения отвечают сотни разных генов, нет какого-то одного. Поэтому люди не могут создать универсальную таблетку от старости и не могут предсказать, когда человек умрет, сколько он будет жить. Но можно влиять на некоторые процессы. Два ярких примера — это уровень гормонов и состояние кожи. Начнем с гормонов. У мужчин уровень тестостерона достигает пика к 25–30 годам, потом постепенно падает. Снижение уровня тестостерона — сигнал для организма, что он стареет и пора все функции замедлять. Изначальный уровень тестостерона, который был на пике молодости, у разных людей варьируется. В зависимости от изначального уровня организм по-разному реагирует на внешний тестостерон в виде таблеток (тестостеронозаместительная терапия). Она позволяет мужчинам поддерживать молодость. Примерно такая же история у женщин, только с женскими гормонами. Сейчас это модно называется антиэйдж-терапия, а в реальности это гормонозаместительная терапия, технологии уже лет двадцать. Фактически людям после 35–40 лет рекомендуют принимать определенную дозу гормонов, чтобы поддерживать уровень собственных гормонов. Для женщин это означает отложенную менопаузу, для мужчин — поддержание тестостерона на нужном уровне. Это влияет на ваше состояние, ты постареешь позже, чем мог бы. Насколько позже — зависит и от человека, и от того, что ему прописывают врачи. Как правило, удается отложить процесс старения на десять лет».
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А если я пойду, например, в «Инвитро» и сдам тест на уровень гормонов, этого не будет достаточно?
«Этот тест покажет некий уровень гормонов на данный момент, но вам не скажут, этот уровень снизился или он такой и был. Изначальный уровень покажет генетический тест. Поэтому вам нужны результаты обоих тестов: биохимического и генетического. Это позволит врачу — гинекологу-эндокринологу понимать, до какого уровня нужно поднимать уровень гормонов, чтобы продлить молодость организма».
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Как ДНК-тест поможет работать с состоянием кожи?
Как ДНК-тест поможет работать с состоянием кожи?
«Тут все гораздо проще. Дряхлость или упругость кожи зависит от того, в каком состоянии находятся разные коллагеновые волокна. Генов коллагенов очень много, у них бывают разные мутации, разные вариации. Все средства ухода, которые содержат коллаген, в плане действия этого коллагена бессмысленны, так как он не может проникать сквозь кожу. Изучая гены белков-коллагенов, можно предположить, как будет кожа стареть. У кого-то она будет стареть быстрее, у кого-то медленнее. Причем скорость старения зависит и от реакции кожи на ультрафиолет, это генетическая проблема. Если у человека есть склонность к фотостарению кожи, то ему нужно пользоваться солнцезащитными кремами по максимуму. Если у него нет склонности — можно пользоваться чуть меньше. Вопрос, какой крем выбрать: одному понадобится защита SPF 50 и больше, другому достаточно защиты SPF 30. Загар для разных людей может быть по-разному полезен или вреден. С одной стороны, воздействие солнца помогает в выработке витамина D, с другой — увеличивает риск меланомы и старения кожи. Каждому человеку стоит сопоставлять любые возможные риски и пользу. Если у человека генетически есть риск меланомы, то, мне кажется, стоит отказаться от загара, чтобы прожить дольше».
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САМЫЙ ЯРКИЙ И ИЗВЕСТНЫЙ ВСЕМ ПРИМЕР ИСКЛЮЧЕНИЯ РИСКОВ — СЛУЧАЙ АНЖЕЛИНЫ ДЖОЛИ. РЕЗУЛЬТАТЫ ЕЕ ДНК-ТЕСТА СВИДЕТЕЛЬСТВОВАЛИ О РИСКЕ ЗАБОЛЕВАНИЯ РАКОМ ГРУДИ (87 %) И РАКОМ ЯИЧНИКОВ (50 %). ЗА ЭТО ОТВЕЧАЕТ ГЕН BRCA1, ОБНАРУЖЕННЫЙ В ЕЕ ОРГАНИЗМЕ. С УЧЕТОМ ЭТИХ ИССЛЕДОВАНИЙ И СМЕРТИ ЕЕ МАТЕРИ ОТ РАКА ЯИЧНИКОВ В 56 ЛЕТ АКТРИСА ПРИНЯЛА РЕШЕНИЕ СДЕЛАТЬ ДВОЙНУЮ МАСТЭКТОМИЮ (ОПЕРАЦИЯ ПО УДАЛЕНИЮ ГРУДИ).
Как называются все эти тесты?
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Уход за кожей на основе ДНК-теста
В сентябре 2014 года был запущен британский косметический бренд GENEU, который предлагает создание сывороток для ухода за кожей на основании ДНК-теста и данных анкеты о вашем стиле жизни. Разработчик технологии — профессор медицинской инженерии Имперского колледжа Лондона Кристофер Тумазу — выбрал для теста два гена, которые, судя по клиническим исследованиям, оказывают наибольшее влияние на старение кожи. Анализ ДНК позволяет подобрать наиболее верное соотношение компонентов каждой сыворотки, соответствующее возможностям кожи конкретного человека. Предполагается, что изобретенный Тумазу микрочип позволит также со временем быстро определять, как организм человека взаимодействует с различными лекарствами, чтобы подбирать точные дозы вещества, необходимые различным пациентам.
«На коллаген и фотостарение у нас есть тест «Здоровье и долголетие», там в том числе показываются риски развития многих мультифакторных заболеваний: онкология, критические заболевания (инсульт, инфаркт, диабет и так далее). На тему питания — тест «Диета и фитнес». На самом деле кроме таких базовых вещей, как старение можно с помощью генетики предсказывать другие реакции. Например, реакция на лекарственные препараты. Сейчас начало волны новых косметических средств, которые назначаются в зависимости от результата генетического теста. Пока что их мало, так как прежде, чем создать такой препарат, нужно произвести серьезное исследование. Но они уже начинают появляться на рынке. Скорее всего, через 5–10 лет мы придем к тому, что косметические препараты будут тоже рекомендоваться на основе результатов ДНК-теста».
Как давно ДНК-тесты стали общедоступны?
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«В России генетика давно. А массовые генетические тесты стали появляться начиная с 2008 года. В мире первыми массовые генетические тесты запустила компания 23andMe, она была основана в 2006 году. За все время их существования порядка 5 миллионов человек в Штатах сдали генетические тесты. А в России только несколько десятков тысяч. Но на развитие у нас влияет еще вопрос менталитета. Генетический тест — это инструмент оценки рисков. Человек узнает о своих рисках и дальше может ими как-то управлять. Не принято в России управлять своими рисками. Большое количество людей живут по принципу «Меньше знаешь — лучше спишь». Поэтому генетические тесты в России менее популярны, чем в Штатах, где люди хотят знать о своих рисках и контролировать свои заболевания. Сейчас и у нас постепенно к этому все движется, сознание меняется, но все равно большая часть населения не готова».
Где и для чего можно сдать ДНК-тест:
«Здоровье и долголетие», «Планирование детей», «Диета и фитнес», «Таланты и спорт», «Генеалогия».
19 990 руб. — первый ДНК-тест. Любой последующий тест на другую тематику — 4990 руб.
Единственная в России частная компания, осуществляющая общедоступные ДНК-тесты, с собственной крупной лабораторией. Помимо работы с частными клиентами осуществляют генетические исследования для научно-исследовательских институтов.
ДНК-тест + анализ состояния кожи и факторов, влияющих на это (экология, образ жизни, обмен веществ)
«Здоровье», «Питание», «Спорт», «Происхождение», «Личные качества».
ДНК-тест + анализ состояния кожи, — 350 евро. Индивидуальный набор косметики — от 400 евро.
29 900 руб. (тест и бесплатная онлайн-консультация врача-генетика)
Центры инновационной медицины Quale Vita работают в тесном сотрудничестве с известными врачами Европы в области превентивной (в том числе гормонозамести-тельной) медицины и являются почетными членами Американской академии медицины за продление жизни (A4M). На основе генетических тестов составляются различные программы здоровья и красоты, например, программа ухода за кожей SEPAI GEN DECODE, направленная на разработку индивидуального набора косметики. Центры Quale Vita находятся в Брюсселе и Барселоне, имеют представительство в Андорре, а в Москве есть контактный центр и авторизо-ванная лаборатория, в которой можно сдать тест (он будет отправлен в Барселону).
Биомедицинский холдинг «Атлас» — это группа компаний в области персонализированной медицины, которая занимается разработками в области генетики и молекулярной диагностики. Флагманские продукты «Атласа» — генетический тест и исследования микробиоты (бактерий кишечника). Также в холдинг входит одноименная клиника, которая предоставляет услуги врачей по 26 терапевтическим направлениям. Для выделения генома компания сотрудничает с лабораторией НИИ физико-химической медицины в Москве.
Центр красоты Aldo Coppola Жуковка/Барвиха
Новое направление Aldo Coppola — комплексный подход к продлению молодости организма, основанный на методах доказательной медицины и с применением различных методов диагностики. Комплекс включает в себя пять этапов:
1. Экспресс-диагностика и консультации.
2. Индивидуальные лабораторные чек-апы.
3. Генетические исследования и выдача генетического паспорта.
4. Индивидуальная программа от anti-age-терапевта.
5. Медицинская эстетика — индивидуальные программы с аппаратными и авторскими мануальными методиками.
«Здоровье и долголетие», «Планирование детей», «Диета и фитнес», «Таланты и спорт», «Генеалогия».
тест на 28 генов — 38 000 руб. Консультация врача-диетолога — 5700 руб. Составление плана питания на неделю — 5700 руб
Вы можете пройти весь комплекс исследований или выбрать одно из направлений. Например, программу по персонализированному питанию: с учетом данных ДНК-теста врач-диетолог еженедельно составляет для вас меню и корректирует его в зависимости от результатов.
ДНК-тест проводится в генетической лаборатории в Новосибирске.
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